I’ve been listening to some of Rhonda Patrick Phd’s stuff recently and was intrigued when I heard her explain a potential mechanism for increased LDL on Robb Wolf’s podcast that I hadn’t heard before.
Her explanation went something like this:
Systemic inflammation leads to inflammation in the gut which then causes bacterial lipopolysaccharide (LPS), an endotoxin released by gut bacteria, to leak through the intestinal wall and enter our blood.
Once LPS enters our circulation it binds to LDL particles and prevents them from binding to hepatic LDL receptors.
LDL receptors are the liver’s way of absorbing circulating LDL particles and removing them from the blood stream, so if LDL particles can’t bind to the LDL receptors, this will lead to more LDL particles floating around.
Some of the causes of inflammation they talk about are include chronic stress and diets that are high in processed carbs, gluten, and trans fats.
She also mentions this theory a few times on her own podcast at FoundMyFitness.com.
This explanation may explain the relationship between periodontal disease and high cholesterol which I touched upon in my prior post, Cholesterol, Inflammation, and Gum Disease.
Since I learned that my mouth is colonized by particularly pathogenic bacteria as shown on my MyPerioPath Results, I could’ve been leaking LPS into my blood stream from my mouth, which could then cause my LDL and LP-PLA2 to be elevated.
Or maybe I had something else going on in my gut that was leaking LPS into my blood that the Bionic Fiber and Probiotics helped to heal.
*Image found here