I’ve been listening to some of Rhonda Patrick Phd’s stuff recently and was intrigued when I heard her explain a potential mechanism for increased LDL on Robb Wolf’s podcast that I hadn’t heard before.
Her explanation went something like this:
Systemic inflammation leads to inflammation in the gut which then causes bacterial lipopolysaccharide (LPS), an endotoxin released by gut bacteria, to leak through the intestinal wall and enter our blood.
Once LPS enters our circulation it binds to LDL particles and prevents them from binding to hepatic LDL receptors.… Read More